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21 February 2022 | ARTICLE
Accuracy of parents' subjective assessment of paediatric fever with thermometer measured fever in a primary care setting
BACKGROUND: Fever is a common symptom of benign childhood illness but a high fever may be a sign of a serious infection. Temperature is often used by parents to check for illness in their children, and the presence of a high temperature can act as...
Auteurs: George Edwards, Susannah Fleming, Jan Y Verbakel, Ann van den Bruel en Gail Hayward
19 February 2022 | ARTICLE
The impact of COVID-19 on the well-being, education and clinical practice of general practice trainees and trainers: a national cross-sectional study
BACKGROUND: COVID-19 has changed General Practice (GP) education as well as GP clinical activities. These changes have had an impact on the well-being of medical trainees and the role of GP plays in the society. We have therefore aimed to investig...
Auteurs: Lotta Coenen, Louise Vanden Poel, Birgitte Schoenmakers, Arne Van Renterghem, Guy Gielis, Roy Remmen en Nele R Michels
17 February 2022 | ARTICLE
How do people living with chronic conditions and their informal caregivers experience primary care? A phenomenological-hermeneutical study
AIMS AND OBJECTIVES: Gaining insight in how people living with chronic conditions experience primary healthcare within their informal network. BACKGROUND: The primary healthcare system is challenged by the increasing number of people living with c...
Auteurs: Dagje Boeykens, Mustafa Sirimsi, Lotte Timmermans, Maja Lopez Hartmann, Sibyl Anthierens, Hans De Loof, Kristel De Vliegher, veerle Foulon, Ine Huybrechts, Lies Lahousse, Peter Pype, Birgitte Schoenmakers, Peter Van Bogaert, Kris Van de Broeck, Ann Van Hecke, Nick Verhaeghe, Mieke Vermandere, Emily Verté, Dominique Van de Velde en Patricia De Vriendt
7 February 2022 | ARTICLE
Risk assessment for endometrial cancer in women with abnormal vaginal bleeding: Results from the prospective IETA-1 cohort study
OBJECTIVE: To investigate the association between personal history, anthropometric features and lifestyle characteristics and endometrial malignancy in women with abnormal vaginal bleeding. METHODS: Prospective observational cohort assessed by des...
Auteurs: Jan Yvan Verbakel, Ruben Heremans, Laure Wynants, Elisabeth Epstein, Bavo De Cock, Maria Angela Pascual, Francesco Paolo Giuseppe Leone, Povilas Sladkevicius, Juan Luis Alcazar, Catherine Van Pachterbeke, Ligita Jokubkiene, Robert Fruscio, Tom Bourne, Ben Van Calster, Dirk Timmerman en Thierry Van den Bosch
1 February 2022 | ARTICLE
Prospective SARS-CoV-2 cohort study among primary health care providers during the second COVID-19 wave in Flanders, Belgium
BACKGROUND: Primary health care providers (PHCPs) are assumed to be at high risk of a COVID-19 infection, as they are exposed to patients with usually less personal protective equipment (PPE) than other frontline health care workers (HCWs). Nevert...
Auteurs: Joachim Marien, Ann Ceulemans, Diana Bakokimi, Christine Lammens, Margareta Ieven, Stefan Heytens, An De Sutter, Jan Y Verbakel, Ann Van den Bruel, Herman Goossens, Pierre Van Damme, Kevin K Arien en Samuel Coenen
29 January 2022 | ARTICLE
The concept of disability and its causal mechanisms in older people over time from a theoretical perspective: a literature review
Ageing with a disability increases the risk of hospitalization and nursing home admission. Ageing in place interventions aiming to reduce disability are often not sufficiently effective and inadequately theory-based. There are many models availabl...
Auteurs: Ines Mouchaers, Hilde Verbeek, Gertrudis Kempen, Jolanda van Haastregt, Ellen Vlaeyen, Geert Goderis en Silke Metzelthin
29 January 2022 | ARTICLE
COVID-19 cases, hospitalizations and deaths in Belgian nursing homes: results of a surveillance conducted between April and December 2020
BACKGROUND: In Belgium, the first COVID-19 death was reported on 10 March 2020. Nursing home (NH) residents are particularly vulnerable for COVID-19, making it essential to follow-up the spread of COVID-19 in this setting. This manuscript describe...
Auteurs: Eline Vandael, Katrien Latour, Esma Islamaj, Laura Int Panis, Milena Callies, Freek Haarhuis, Kristiaan Proesmans, Brecht Devleesschauwer, Javiera Rebolledo Gonzalez, Alice Hannecart, Romain Mahieu, Louise de Viron, Etienne De Clercq, Anne Kongs, Naima Hammami, Jean-Marc Francois, Dominique Dubourg, Sarah Henz, Boudewijn Catry en Sara Dequeker
28 January 2022 | ARTICLE
How are family caregivers of people with a serious illness supported by healthcare professionals in their caregiving tasks? A cross-sectional survey of bereaved family caregivers
BACKGROUND: Due to medical advances and an increasingly ageing population, the number of people living with a serious illness is rising. This has major implications for the burden on family members of assisting with care. Support of family caregiv...
Auteurs: Orphe Matthys, Sigrid Dierickx, Luc Deliens, Lore Lapeire, Peter Hudson, Chantal Van Audenhove, Aline De Vleminck en Joachim Cohen
20 January 2022 | ARTICLE
Efficacy of a theory-driven program to implement alcohol screening and brief interventions in primary health-care: a cluster randomized controlled trial
BACKGROUND AND AIMS: Screening and brief interventions (SBI) in primary health-care practices (PHCP) are effective in reducing reported alcohol consumption, but have not been routinely implemented. Most programs seeking to improve implementation r...
Auteurs: Frederico Rosario, Milica Vasiljevic, Leo Pas, Colin Angus, Cristina Ribeiro en Niamh Fitzgerald
20 January 2022 | OTHER
Evaluation of Point of Care Tests in primary care: bridging the gap
Diagnostic testing forms the backbone of a large proportion of public healthcare, informing decisions about treatment, specialty referral and hospital admission. Over the past few decades, diagnostic technologies have become cheaper, smaller, and ...
Auteurs: Jan Verbakel
20 January 2022 | ARTICLE
The Impact of Dementia's Affiliate Stigma on the Mental Health of Relatives: A Cross Section Survey
OBJECTIVE: To determine the impact of the affiliate stigma on mental well-being of relatives caring for a person with dementia. DESIGN: The study was conducted in a cross sectional design. SETTING: The study was conducted in a public setting, addr...
Auteurs: Pauline van den Bossche en Birgitte Schoenmakers
17 January 2022 | ARTICLE
Biomarkers of acute kidney injury after pediatric cardiac surgery: a meta-analysis of diagnostic test accuracy
Acute kidney injury (AKI) occurs frequently after cardiac surgery in children. Although current diagnostic criteria rely on serum creatinine and urine output, changes occur only after considerable loss of kidney function. This meta-analysis aimed ...
Auteurs: Jef Van den Eynde, Art Schuermans, Jan Y Verbakel, Marc Gewillig, Shelby Kutty, Karel Allegaert en Djalila Mekahli
11 January 2022 | ARTICLE
Cost-effectiveness of check of medication appropriateness: methodological approach
Background Adverse drug events following inappropriate prescribing in the hospital cause a substantial and avoidable medical and economic burden to hospitals, payers and patients alike. A clinical rule-based, pharmacist-led medication-review servi...
Auteurs: Erinn D'hulster, Charlotte Quintens, Raf Bisschops, Rik Willems, Willy E Peetermans, Jan Y Verbakel en Jeroen Luyten
Auteurs: Peter YK Van den Bergh, Pieter A van Doorn, Robert DM Hadden, Bert Avau, Patrik Vankrunkelsven, Jeffrey A Allen, Shahram Attarian, Patricia H Blomkwist-Markens, David R Cornblath, Filip Eftimov, H Stephan Goedee, Thomas Harbo, Satoshi Kuwabara, Richard A Lewis, Michael P Lunn, Eduardo Nobile-Orazio, Luis Querol, Yusuf A Rajabally, Claudia Sommer en Haluk A Topaloglu
10 January 2022 | ARTICLE
Control in the Hospital by Extensive Clinical rules for Unplanned hospitalizations in older Patients (CHECkUP); study design of a multicentre randomized study
BACKGROUND: Due to ageing of the population the incidence of multimorbidity and polypharmacy is rising. Polypharmacy is a risk factor for medication-related (re)admission and therefore places a significant burden on the healthcare system. The repo...
Auteurs: Aimee EMJH Linkens, Vanja Milosevic, Noemi van Nie, Anne Zwietering, Peter W de Leeuw, Marjan van den Akker, Jos MGA Schols, Silvia MAA Evers, Carlota Mestres Gonzalvo, Bjorn Winkens, Bob PA van de Loo, Louis de Wolf, Lucretia Peeters, Monique de Ree, Bart Spaetgens, Kim PGM Hurkens en Hugo M van der Kuy
5 January 2022 | ARTICLE
Resilience in advanced cancer caregiving. A systematic review and meta-synthesis
BACKGROUND: Close relatives provide much of the care to people with cancer. As resilience can shield family caregivers from mental health problems, there has been a burgeoning interest in resilience-promoting interventions. However, the evidence n...
Auteurs: Sophie Opsomer, Emelien Lauwerier, Jan De Lepeleire en Peter Pype
5 January 2022 | ARTICLE
Resilience in advanced cancer caregiving. A systematic review and meta-synthesis
Background: Close relatives provide much of the care to people with cancer. As resilience can shield family caregivers from mental health problems, there has been a burgeoning interest in resilience-promoting interventions. However, the evidence n...
Auteurs: Sophie Opsomer, Emelien Lauwerier, Jan De Lepeleire en Peter Pype
3 January 2022 | ARTICLE
Using Belgian pharmacy dispensing data to assess antibiotic use for children in ambulatory care
BACKGROUND: The desired effect of antibiotics is compromised by the rapid escalation of antimicrobial resistance. Children are particularly at high-risk for unnecessary antibiotic prescribing, which is owing to clinicians' diagnostic uncertainty c...
Auteurs: Hannelore Dillen, Ruben Burvenich, Tine De Burghgraeve en Jan Y Verbakel
1 January 2022 | ARTICLE
Antibiotic prescribing rate after optimal near-patient C-reactive protein testing in acutely ill children presenting to ambulatory care (ARON project): protocol for a cluster-randomized pragmatic trial
INTRODUCTION: Children become ill quite often, mainly because of infections, most of which can be managed in the community. Many children are prescribed antibiotics which contributes to antimicrobial resistance and reinforces health-seeking behavi...
Auteurs: Jan Yvan Jos Verbakel, Tine De Burghgraeve, Ann Van den Bruel, Samuel Coenen, Sibyl Anthierens, Louise Joly, Annouschka Laenen, Jeroen Luyten en An De Sutter
1 January 2022 | ARTICLE
Everyday Lives of Middle-Aged Persons with Multimorbidity: A Mixed Methods Systematic Review
The healthcare burden of patients with multimorbidity may negatively affect their family lives, leisure time and professional activities. This mixed methods systematic review synthesizes studies to assess how multimorbidity affects the everyday li...
Auteurs: Ana Isabel Gonzalez-Gonzalez, Robin Bruenn, Julia Nothacker, Christine Schwarz, Edris Nury, Truc Sophia Dinh, Maria-Sophie Brueckle, Mirjam Dieckelmann, Beate Sigrid Mueller en Marjan van den Akker
1 January 2022 | ARTICLE
Mental Health Promotion and Intervention in Occupational Settings: Protocol for a Pilot Study of the MENTUPP Intervention
Depression and anxiety are the most prevalent mental health difficulties in the EU, causing immense suffering and costing the global economy EUR 1 trillion each year in lost productivity. Employees in construction, health and information and commu...
Auteurs: Ella Arensman, Cliodhna O'Connor, Caleb Leduc, Eve Griffin, Grace Cully, Doireann Ni Dhalaigh, Carolyn Holland, Chantal Van Audenhove, Evelien Coppens, Fotini Tsantila, Victoria Ross, Birgit Aust, Arlinda Cerga Pashoja, Johanna Cresswell-Smith, Laura Cox, Lars de Winter, Naim Fanaj, Birgit A Greiner, Ulrich Hegerl, Sharna Mathieu, Ana Moreno-Alcazar, Wendy Orchard, Charlotte Paterson, Gyoergy Purebl, Gentiana Qirjako, Hanna Reich en Paul Corcoran
1 January 2022 | ARTICLE
Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis
Evidence-based clinical guidelines generally consider single conditions, and rarely multimorbidity. We developed an evidence-based guideline for a structured care program to manage polypharmacy in multimorbidity by using a realist synthesis to upd...
Auteurs: Truc Sophia Dinh, Maria-Sophie Brueckle, Ana Isabel Gonzalez-Gonzalez, Joachim Fessler, Ursula Marschall, Manfred Schubert-Zsilavesz, Ferdinand M Gerlach, Sebastian Harder, Marjan van den Akker, Ingrid Schubert en Christiane Muth
1 January 2022 | ARTICLE
Prevalence and incidence of antibodies against SARS-CoV-2 among primary healthcare providers in Belgium during 1 year of the COVID-19 epidemic: prospective cohort study protocol
INTRODUCTION: National SARS-CoV-2 seroprevalence data provide essential information about population exposure to the virus and help predict the future course of the epidemic. Early cohort studies have suggested declines in levels of antibodies in ...
Auteurs: Niels Adriaenssens, Beatrice Scholtes, Robin Bruyndonckx, Jan Y Verbakel, An De Sutter, Stefan Heytens, Ann van den Bruel, Isabelle Desombere, Pierre van Damme, Herman Goossens, Laetitia Buret, Els Duysburgh en Samuel Coenen
1 January 2022 | ARTICLE
The Effects of Heatwaves on Human Morbidity in Primary Care Settings: A Case-Crossover Study
PURPOSE: This study assesses the potential acute effects of heatwaves on human morbidities in primary care settings. METHODS: We performed a time-stratified case-crossover study to assess the acute effects of heatwaves on selected morbidities in p...
Auteurs: Mahmoud Alsaiqali, Katrien De Troeyer, Lidia Casas, Rafiq Hamdi, Christel Faes en Gijs Van Pottelbergh
Auteurs: Aniana Declercq, R Droës, M Mittelman en Chantal Van Audenhove
30 December 2021 | ARTICLE
Pneumococcal vaccination prevented severe LRTIs in adults: a causal inference framework applied in registry data
OBJECTIVES: We estimated the effect of pneumococcal vaccination (PV) on acute lower respiratory tract infections (LRTIs) in various age and risk groups using different methods within a causal inference methodological framework. STUDY DESIGN AND SE...
Auteurs: Pavlos Mamouris, Severine Henrard, Geert Molenberghs, Jan Verhaegen, Guohao Lin en Bert Vaes
27 December 2021 | ARTICLE
"So hard not to feel blamed!": Assessment of implementation of Benin's Maternal and Perinatal Death Surveillance and Response strategy from 2016-2018
OBJECTIVE: To assess the implementation of the Maternal and Perinatal Death Surveillance and Response (MPDSR) strategy institutionalized in Benin in 2013 to address the alarmingly high maternal and neonatal death rates. METHODS: A retrospective, m...
Auteurs: Christelle Boyi Hounsou, Mahugnon CU Agossou, Kefilath Bello, Therese Delvaux, Lenka Benova, Armelle Vigan Guezodje, Hashim Hounkpatin en Jean-Paul Dossou
20 December 2021 | ARTICLE
Remote versus on-site proctored exam: comparing student results in a cross-sectional study
BACKGROUND: The COVID-19 pandemic has profoundly affected assessment practices in medical education necessitating distancing from the traditional classroom. However, safeguarding academic integrity is of particular importance for high-stakes medic...
Auteurs: Vasiliki Andreou, Sanne Peters, Jan Eggermont, Johan Wens en Birgitte Schoenmakers
11 December 2021 | ARTICLE
Political economy analysis of universal health coverage and health financing reforms in low- and middle-income countries: the role of stakeholder engagement in the research process
BACKGROUND: Progress towards universal health coverage (UHC) is an inherently political process. Political economy analysis (PEA) is gaining momentum as a tool to better understand the role of the political and economic dimensions in shaping and a...
Auteurs: Giulia Loffreda, Kefilath Bello, Joel Arthur Kiendrebeogo, Isidore Selenou, Mohamed Ali Ag Ahmed, Jean Paul Dossou, Sophie Witter en Maria Paola Bertone